Loss of Cortical SSEP Due To Loss of Receptor Activation

Earlier in this 30 Days of Neuromonitoring series, I wrote about cortical and subcortical reorganization after a loss of afferent feedback from carpal tunnel syndrome and how that affects intraoperative somatosensory evoked potentials. To follow along those same lines, I’d like to reference another study by (Valeriani, 1996) titled Central nervous system modifications in patients with lesion of the anterior cruciate ligament of the knee (similar topic, but this one deals with the receptor).

In this study, they again looked at the effects that loss of afferent information has on our central nervous system and our ability to record physiologic responses. In this case, they studied patients with loss of proprioception in the knee after injury to the anterior cruciate ligament. Their 2 major finding were the following:

  • The common peroneal nerve showed loss of cortical SSEPs, but no real loss in subcortical and spinal amplitudes. In the diagnostic world, that usually means something causing a conduction block along the medial lemniscus. In the intraoperative neuromonitoring world, we tend to think conduction block in medial lemniscus due to preexisting lesion, pre-existing ischemic changes (which we can sometimes jump the gun a little bit on) or anesthetic effects. But their second finding eliminated those options.
  • These same findings were not seen with stimulation to the posterior tibial nerve at the knee or ankle, nor the peroneal nerve in the lower leg. They were able to record cortical, subcortical and spinal SSEP from these more distal stimulating sites. This now makes a medial lemniscus conduction block or lesion very low on the probability scale and points to something cortical in nature.

ACL Injury Vs. Carpal Tunnel Syndrome As It Relates To SEP

What we are seeing here is not a loss of conduction of the afferent information, as was discovered with the carpal tunnel group, but a loss of the summation from the receptors themselves. The injury caused damage to the receptor and decreased the day-to-day barrage of proprioceptive input that drives our central nervous system.

innervation of ACL

Since a small but significant portion of the IONM community is made up of chiropractors, physical and occupational therapist, exercise physiologist and other healthcare providers who come from a receptor-based therapy background, this shouldn’t be too shocking. In the application and recording of physical medicine, we look to ramp up areas of deficient afferent input through direct or indirect means.

It’s a leading explanation as to why exercise has one of the best track records for curing depression, or how mirror therapy works as a visual feedback therapy for stroke patients, etc.

This is just the measurement of the reverse happening. Loss of receptor activation – leads to loss of central neuronal activation – leads to reorganization of surrounding structures as a means to cope.

Enough Chiropractic – How Might This Be Useful In Neuromonitoring?

I had four major thoughts from this paper:

  1. The ability to feel a cotton swab or pin prick is not the only way to assess sensory afferents. Proprioception and 2-point discrimination are also of value when recording somatosensory evoked potentials. This could be an additional reason as to why some patients have poor SSEP even though they can “feel” everything.
  2. In any patient with a history of loss of afferent input, alternative stimulating locations need to be planned for ahead of time. Always be planning for optimization.
  3. This paper only showed cortical changes, while the carpal tunnel had both cortical and subcortical changes. Is the degree of loss of afferent firing the cause?
  4. This paper and the carpal tunnel paper showed 2 different ways SSEP can be affected by a loss of afferent input. They both showed to have reorganization over the areas specific to the somatotopic representation of that anatomical area with an afferent deficit. Might we carry this over to other common scenarios that we encounter as surgical neurophysiologist (you should be thinking spinal injury here)? While it is well accepted that the muscles that control fine movement have a higher density of muscle spindles, it might not be widely appreciated as to the amount in the cervical spine versus other areas (see numbers below). What about a loss of afferent input from the cervical spine for our MVA patients? While we aren’t running an SSEP off of a cervical nerve root or anything, the sheer amount of afferent input might affect the overall cortical drive, and in return smaller cortical SSEP overall. (Sorry, some more chiropractic thoughts: this last one is a theory, still looking for a paper for some validity. But I know that chiropractors would love to see something like this. Lowered cortical output due to spinal injury >>> manipulation of the spine causing a fast stretch to muscles, possibly resetting the gain of the muscle spindle cells >>> improved afferent feedback >>> improved SSEP).

muscle spindle ssep

Density of Muscle Spindles Per Gram Of Muscle Tissue

Inferior Oblique 242

Superior Oblique 190

Rectus Capitis Posterior Major 98

Rectus Capitis Posterior Minor 98

Lateral Pterygoid 20.3

Opponens Pollicis 17.3

First Lumbrical 16.5

Trapezius 2.2

Latissimus Dorsi 1.4

Medial Pterygoid 0

Does anyone else have another take on this article as it relates to intraoperative neuromonitoring that I didn’t consider? I always like to hear other people’s perspective on things, especially when it isn’t exactly a straight line to come to some sort of conclusion. There isn’t much talk about the effect of the receptor on our SSEP, especially considering the fact that we bypass the receptors with electric current directly stimulating the nerve.

Just place your comment in the section below.

 

Joe Hartman DC, DACNB, DABNM

Joe Hartman DC, DACNB, DABNM

Vice President Of Clinical Services - Sentient Medical

Joe came into the neuromonitoring field as a board-certified chiropractic neurologist with an interest in neurodiagnostics. After earning a diplomate from the American Board of Neurophysiologic Monitoring, he started IntraoperativeNeuromonitoring.com as a resource for other surgical neurophysiologist looking to learn and discuss all things neuromonitoring. Once he started work at Sentient Medical in 2016, the website was relaunched and expanded to include webinars, polls, practice test and a forum. He spends more time tinkering on this website in his spare time than he cares to admit.

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